Fitoterapia, 2021-03, Vol.149, p.104823, Article 104823
2021
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- Autor(en) / Beteiligte
- Titel
- Bioactive cyclohexene derivatives from a mangrove-derived fungus Cladosporium sp. JJM22
- Ist Teil von
- Fitoterapia, 2021-03, Vol.149, p.104823, Article 104823
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Four new cyclohexene derivatives cladoscyclitols A–D (1–4) and one new ribofuranose phenol derivative 4-O-α-D-ribofuranose-2-pentyl-3-phemethylol (5) were obtained from the EtOAC extract of the mangrove-derived endophytic fungus Cladosporium sp. JJM22. The structures were elucidated by extensive NMR and MS analysis, while the absolute configurations of the stereogenic carbons were established based on quantum-chemical electronic circular dichroism calculations or comparison of the optical rotations with those of related compounds. Compounds 2 and 5 displayed potent inhibitory activity against α-glucosidase with the IC50 values of 2.95 and 2.05 μM, respectively. [Display omitted]
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0367-326XeISSN: 1873-6971DOI: 10.1016/j.fitote.2020.104823Titel-ID: cdi_pubmed_primary_33387642
- Format
- –
- Schlagworte
- Ceriops tagal, China, Circular dichroism, Cladosporium, Cladosporium - chemistry, Cladosporium sp, Cyclohexene, Cyclohexene derivatives, Cyclohexenes - isolation & purification, Cyclohexenes - pharmacology, Dichroism, Endophytes, Endophytes - chemistry, Fungi, Glucosidase, Glycoside Hydrolase Inhibitors - isolation & purification, Glycoside Hydrolase Inhibitors - pharmacology, Microbial Sensitivity Tests, Molecular Structure, NMR, Nuclear magnetic resonance, Phenols, Quantum chemistry, Rhizophoraceae - microbiology, Ribofuranose phenol, α-Glucosidase