Details

Autor(en) / Beteiligte

• Hamada, Masami
• Kajita, Etsuko
• Tamaki, Junko
• Kouda, Katsuyasu
• Sato, Yuho
• Tachiki, Takahiro
• Yura, Akiko
• Kamiya, Kuniyasu
• Nitta, Akemi
• Kagamimori, Sadanobu
• Iki, Masayuki

Titel

Decreased bone mineral density and osteoporotic fractures are associated with the development of echogenic plaques in the carotid arteries over a 10-year follow-up period: The Japanese Population-based Osteoporosis (JPOS) Cohort Study

Ist Teil von

• Maturitas, 2020-01, Vol.131, p.40-47

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• •Echogenic carotid plaques are a strong predictor of cardiovascular disease.•Low bone density and fracture history were linked with echogenic plaque development.•This association did not alter after adjustment for risk factors for cardiovascular diseases.•Women with osteoporosis may be a target population for screening for cardiovascular disease. To investigate whether low bone mineral density (BMD) and history of fracture at baseline are associated with the development of echogenic carotid plaques over a 10-year follow-up period. A prospective cohort study. Development of echogenic plaques identified by ultrasonography of the carotid arteries. Among 1048 women aged 40 or more who completed the baseline survey of the Japanese Population-based Osteoporosis (JPOS) cohort study, 500 women who completed the first decade of follow-up and 267 women who completed the second decade of follow-up were included. We identified history and incidence of clinical osteoporotic fracture during the follow-up through medical interviews, and determined vertebral fractures by morphometry of absorptiometric images. We identified 67 (13.4%) and 31 (11.6%) women with echogenic plaques at the end of first and second decade of follow-up, respectively. Participants with echogenic plaques were significantly older, exhibited lower spine BMD, and had a higher prevalence of osteoporotic fracture, diabetes, and hypertension. A generalized estimating equation analysis was used to combine the participants from the two follow-up periods into a single cohort, and showed that osteoporotic BMD and osteoporotic fractures were significantly associated with the development of echogenic plaques, after adjusting for atherosclerosis risk factors (odds ratio (OR): 2.15, 95% confidence interval (95% CI): 1.04, 4.44; OR: 1.84, 95% CI: 1.03, 3.28, respectively). Osteoporotic BMD and osteoporotic fracture history were significantly, and independently, associated with an increased occurrence of echogenic plaques. Ultrasonographic screening of the carotid artery may benefit patients with osteoporosis.