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Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders – A systematic review and meta-analysis
Ist Teil von
Frontiers in neuroendocrinology, 2019-10, Vol.55, p.100792-100792, Article 100792
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
•Depressed men had significantly lower testosterone than healthy controls.•No alterations in follicle-stimulating hormone or luteinising hormone were observed.•Sampling tissue and BMI were effect modifiers regarding testosterone.
Sexual dysfunctions are common in men with depression. As the hypothalamic-pituitary-gonadal (HPG) axis is a crucial regulator of sexual function, and also affects mood and cognition, the following question arises: Is the HPG axis altered in depressed men when compared to healthy controls?
To answer this question, PubMed and PsycINFO were searched. Inclusion criteria for the systematic review and meta-analysis were: (1) case-control study including male patients with a depressive disorder and (2) assessment of follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, or testosterone.
Seventeen studies were identified. Follicle-stimulating hormone and LH did not differ between patients and controls. By contrast, in patients, oestradiol was marginally increased (g = 0.52, 95% CI [−0.01, 1.04]; Z = 1.92, p = .055) and testosterone was significantly decreased (g = −0.45, 95% CI [−0.80, −0.10]; Z = −2.53, p = .012).
Depressed men may be characterised by diminished testosterone and potentially elevated oestradiol, which beyond contributing to sexual dysfunction, could impact mood and cognition.