Details

Autor(en) / Beteiligte

• Mariani, Rachel A
• Silva, Mercedes
• Caparelli, Edward
• Jennings, Lawrence J
• Yap, Kai Lee
• Leuer, Katrin M
• Weinstein, Joanna
• Gong, Shunyou

Titel

Inv(11)(q21q23); KMT2A-MAML2, a Recurrent Genetic Abnormality in T-Cell Therapy-related Acute Lymphoblastic Leukemia

Ist Teil von

• Journal of pediatric hematology/oncology, 2020-05, Vol.42 (4), p.e258

Ort / Verlag

United States

Erscheinungsjahr

2020

Link zum Volltext

Beschreibungen/Notizen

• T-cell therapy-related acute lymphoblastic leukemia (T-t-ALL) is a rare condition associated with previous cytotoxic therapy for another disease. Here we report T-t-ALL with inv(11)(q21q23), which involves KMT2A and MAML2, a transcriptional coactivator of NOTCH proteins, that occurred after chemotherapy for Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia. This case describes the youngest patient with T-t-ALL harboring inv(11)(q21q23) and is the first independent report following an initial series also occurring in children. Our results lend further support to the observation that the KMT2A-MAML2 fusion gene resulting from inv(11)(q21q23) is likely a recurrent cytogenetic abnormality in T-t-ALL and appears to be associated with pediatric cases.