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Therapeutic implications of novel peptides targeting ER-mitochondria Ca 2+ -flux systems
Ist Teil von
Drug discovery today, 2019-05, Vol.24 (5), p.1092
Ort / Verlag
England
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
Intracellular Ca
-flux systems located at the ER-mitochondrial axis govern mitochondrial Ca
balance and cell fate. Multiple yet incurable pathologies are characterized by insufficient or excessive Ca
fluxes toward the mitochondria, in turn leading to aberrant cell life or death dynamics. The discovery and ongoing molecular characterization of the main interorganellar Ca
gateways have resulted in a novel class of peptide tools able to regulate relevant protein-protein interactions (PPIs) underlying this signaling scenario. Here, we review peptides, molecularly derived from Ca
-flux systems or their accessory proteins. We discuss how they alter Ca
-signaling protein complexes and modulate cell survival in light of their forthcoming therapeutic applications.