Autor(en)
Tsikolia, Maia; Bernier, Ulrich R; Agramonte, Natasha M; Estep, Alden S; Becnel, James J; Tabanca, Nurhayat; Linthicum, Kenneth J; Gross, Aaron D; Guerin, Patrick M; Krober, Thomas; Bloomquist, Jeffrey R
Titel
Insecticidal and repellent properties of novel trifluoromethylphenyl amides II
Teil von
  • Pesticide biochemistry and physiology, 2018-10-01, Vol.151, p.40-46
Ort / Verlag
SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE
Links zum Volltext
Quelle
Web of Science
Beschreibungen
This project focused on the design, synthesis, and testing of trifluoromethylphenyl amides (TFMPAs) as potential mosquitocides and repellents. Fourteen compounds were evaluated for toxicity against larvae and adults of Aedes aegypti. Several compounds were toxic against Aedes aegypti (larval, adult and feeding bioassays) and Drosophila melanogaster (glass-surface contact assay), but were much less toxic than fipronil, with toxicity ratios ranging from 100-fold in the larval assay to 100,000-fold for topical application to adult insects. In repellency bioassays to determine minimum effective dosage (MED), compound N-(2,6-dichloro-4(trifluoromethyl)phenyl)-2,2,3,3,3-pentafluoropropanamide (7b) repelled Ae. aegypti females at lower concentration, 0.017 (+/- 0.006) mu mol/cm(2), than N, N-diethyl-meta-toluamide (DEET) 0.026 (+/- 0.005) mu mol/cm(2). 2-Chloro-N-(3-(trifluoromethyl)phenyl)acetamide (6a) performed better than DEET against two species of mosquitoes: it repelled Ae. aegypti females at 0.013 (+/- 0.006) mu mol/cm(2) and Anopheles gambiae females (in a warm body repellent assay), at a standard exposure of 2 nmol/cm(2). These studies revealed novel active structures that could further lead to compounds with better repellent activity.
Format
Sprache(n)
Englisch
Identifikator(en)
ISSN: 0048-3575
ISSN: 1095-9939
DOI: 10.1016/j.pestbp.2018.08.006
Links zum Inhalt
Schlagwörter
Biochemistry & Molecular Biology, Entomology, Life Sciences & Biomedicine, Physiology, Science & Technology
Systemstelle
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