Details

Autor(en) / Beteiligte

• Li, Luo-Yuan
• Zhou, Yi-Ming
• Gao, Rong-Yao
• Liu, Xiao-Chen
• Du, Hui-Hui
• Zhang, Jia-Ling
• Ai, Xi-Cheng
• Zhang, Jian-Ping
• Fu, Li-Min
• Skibsted, Leif H.

Titel

Naturally occurring nanotube with surface modification as biocompatible, target-specific nanocarrier for cancer phototherapy

Ist Teil von

• Biomaterials, 2019-01, Vol.190-191, p.86-96

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Phototherapy has drawn increasing attention including the use of nanocarriers with high drug loading capacity and delivery efficacy for target-specific therapy. We have made use of naturally-occurring halloysite nanotubes (HNTs) to build a biomimetic nanocarrier platform for target-specific delivery of phototherapeutic agents. The HNTs were decorated with poly(sodium-p-styrenesulfonate) (PSS) to enhance the biocompatibility, and were further functionalized by lumen loading the type-II photosensitizer indocyanine green (ICG). The HNT-PSS-ICG nanocarrier, without further tethering targeting groups, was shown to associate with the membrane of giant unilamellar vesicles (GUVs) via Pickering effects. Application of HNT-PSS-ICG nanocarrier to human breast cancer cells gave rise to a cell mortality as high as 95%. The HNT-PSS-ICG nanocarrier was further coated with MDA-MB-436 cell membranes to endow it with targeting therapy performance against breast cancer, which was confirmed by in vivo experiments using breast cancer tumors in mice. The membrane-coated and biocompatible nanocarrier preferentially concentrated in the tumor tissue, and efficiently decreased the tumor volume by a combination of photodynamic and photothermal effects upon near-infrared light exposure. Our results demonstrate that the HNT-based nanocarrier by virtue of facial preparation and high loading capacity can be a promising candidate for membrane-targeting nanocarriers. Biocompatible halloysite nanotube as target-specific nanocarrier for the application in phototherapy of breast cancer. [Display omitted]