Details

Autor(en) / Beteiligte

• Bansi, Jens
• Koliamitra, Christina
• Bloch, Wilhelm
• Joisten, Niklas
• Schenk, Alexander
• Watson, Matthew
• Kool, Jan
• Langdon, Dawn
• Dalgas, Ulrik
• Kesselring, Jürg
• Zimmer, Philipp

Titel

Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training

Ist Teil von

• Journal of neuroimmunology, 2018-01, Vol.314, p.101-105

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS. Further research is warranted to investigate whether these changes are associated with clinical measures (e.g. depressions and immune function). [Display omitted] •First study to investigate the influence of exercise on Tryptophan metabolism in MS.•Three weeks of exercise increased serotonin levels in different MS subtypes.•MS subtypes indicated different responses of the Kynurenine pathway to exercise.