Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...

Details

Autor(en) / Beteiligte
Titel
Long exposure to type 2 diabetes and risk of non-fatal coronary heart disease in Chinese females and males: Findings from a China national cross-sectional study
Ist Teil von
  • Diabetes research and clinical practice, 2018-03, Vol.137, p.119-127
Ort / Verlag
Ireland: Elsevier B.V
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
  • •We tested gender differences in coronary heart disease (CHD) risk in type 2 diabetes (T2DM).•Long exposure to T2DM imparts a larger CHD risk to females than to males.•The excessive risk couldnot be explained by increased conventional risk factors. To investigate the risk of Chinese females versus males for non-fatal coronary heart disease (CHD) due to long exposure to type 2 diabetes mellitus (T2DM). 223,612 Chinese patients with T2DM were recruited from China in 2012. Binary logistic regression analysis was performed to obtain odds ratios (OR) of females versus males for non-fatal CHD. Additive interaction was used to test whether female gender and long exposure to T2DM (≥15 years) had a synergistic effect for non-fatal CHD. Significant relative excess risk due to interaction (RERI > 0), attributable proportion due to interaction (AP > 0) or synergy index (SI > 1) suggest a significant additive interaction. More females than males with T2DM had non-fatal CHD (11.3% versus 10.6%, P < .0001). Females had slightly higher risk of non-fatal CHD since 5–10 years of diabetic duration and the effect size became larger since 15 years and onwards. Overall effect of females versus males for non-fatal CHD was 1.04 (95% CI: 1.01–1.08) among patients with <15 years of duration while the effect size increased to 1.17 (95% CI: 1.07–1.28) among patients with ≥15 years of duration. Using males with <15 years of duration as the reference, females with ≥15 years of duration were at 1.82-fold (95% CI: 1.70–1.95) non-fatal CHD risk while males with ≥15 years of duration were only at 1.56 (95% CI: 1.45–1.68) fold non-fatal CHD risk, with significant additive interaction (all three measures < 0.05). Long exposure to T2DM imparted a larger risk of non-fatal CHD to Chinese females than to Chinese males.

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX