Details

Autor(en) / Beteiligte

• Marchi, Saverio
• Bittremieux, Mart
• Missiroli, Sonia
• Morganti, Claudia
• Patergnani, Simone
• Sbano, Luigi
• Rimessi, Alessandro
• Kerkhofs, Martijn
• Parys, Jan B
• Bultynck, Geert
• Giorgi, Carlotta
• Pinton, Paolo

Titel

Endoplasmic Reticulum-Mitochondria Communication Through Ca 2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs)

Ist Teil von

• Advances in experimental medicine and biology, 2017, Vol.997, p.49

Ort / Verlag

United States

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• The execution of proper Ca signaling requires close apposition between the endoplasmic reticulum (ER) and mitochondria. Hence, Ca released from the ER is "quasi-synaptically" transferred to mitochondrial matrix, where Ca stimulates mitochondrial ATP synthesis by activating the tricarboxylic acid (TCA) cycle. However, when the Ca transfer is excessive and sustained, mitochondrial Ca overload induces apoptosis by opening the mitochondrial permeability transition pore. A large number of regulatory proteins reside at mitochondria-associated ER membranes (MAMs) to maintain the optimal distance between the organelles and to coordinate the functionality of both ER and mitochondrial Ca transporters or channels. In this chapter, we discuss the different pathways involved in the regulation of ER-mitochondria Ca flux and describe the activities of the various Ca players based on their primary intra-organelle localization.