Details

Autor(en) / Beteiligte

• Raffa, Demetrio
• Maggio, Benedetta
• Raimondi, Maria Valeria
• Plescia, Fabiana
• Daidone, Giuseppe

Titel

Recent discoveries of anticancer flavonoids

Ist Teil von

• European journal of medicinal chemistry, 2017-12, Vol.142, p.213-228

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• In this review we report the recent advances in anticancer activity of the family of natural occurring flavonoids, covering the time span of the last five years. The bibliographic data will be grouped, on the basis of biological information, in two great categories: reports in which the extract plants bioactivity is reported and the identification of each flavonoid is present or not, and reports in which the anticancer activity is attributable to purified and identified flavonoids from plants. Wherever possible, the targets and mechanisms of action as well as the structure-activity relationships of the molecules will be reported. Also, in the review it was thoroughly investigated the recent discovery on flavonoids containing the 2-phenyl-4H-chromen-4-one system even if some examples of unusual flavonoids, bearing a non-aromatic B-ring or other ring condensed to the base structure are reported. [Display omitted] •We report the advances in bioactive flavonoids.•The review cover the time span of the last five years.•The bibliographic data will be grouped, on the basis of biological information.•Wherever possible, some general conclusions on the targets and mechanisms of action are provided.