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Highly resolved HSQC experiments for the fast and accurate measurement of homonuclear and heteronuclear coupling constants
Ist Teil von
Journal of magnetic resonance (1997), 2017-09, Vol.282, p.54-61
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
[Display omitted]
•A multiple-purpose HSQC sequence for the accurate measurement of coupling constants.•A family of six new J-resolved HSQC experiments are described.•Measurement of homo- and heteronuclear coupling constants from J-resolved HSQC.•Highly resolved HSQC experiments to measure the sign and magnitude of JCH and JHH.•Measurement of multiple coupling constants from a single E.COSY-type experiment.
A number of J-upscaled NMR experiments are currently available to measure coupling constants along the indirect F1 dimension of a 2D spectrum. A major drawback is the limited F1 digital resolution that requires long acquisition times in order to achieve reasonably accurate measures. Here is shown how high levels of F1 digital resolution in a multiple-purpose HSQC experiment can be easily achieved by implementing a general J/δ-scaling strategy. In particular, a set of new J-resolved HSQC experiments is presented for a faster and much more accurate J determination in small molecules. Several options and practical aspects are discussed and exemplified by measuring the magnitude and/or the sign of several homo- and heteronuclear coupling constants in one shot.