A number of J-upscaled NMR experiments are currently available to measure coupling constants along the indirect F1 dimension of a 2D spectrum. A major drawback is the limited Fl digital resolution that requires long acquisition times in order to achieve reasonably accurate measures. Here is shown how high levels of Fl digital resolution in a multiple-purpose HSQC experiment can be easily achieved by implementing a general J/delta-scaling strategy. In particular, a set of new J-resolved HSQC experiments is presented for a faster and much more accurate J determination in small molecules. Several options and practical aspects are discussed and exemplified by measuring the magnitude and/or the sign of several homo- and heteronuclear coupling constants in one shot. (C) 2017 Elsevier Inc. All rights reserved.