Details

Autor(en) / Beteiligte

• Lai, Jesyin
• Sommer, Alexandra L.
• Bartlett, Edward L.

Titel

Age-related changes in envelope-following responses at equalized peripheral or central activation

Ist Teil von

• Neurobiology of aging, 2017-10, Vol.58, p.191-200

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Previous work has debated about the comparisons of hearing abilities faced with alterations in hearing thresholds and evoked potentials between groups following acoustic trauma- or age-related changes. This study compares envelope-following responses (EFRs) of young and aged rats when sound levels were matched according to (1) wave I amplitudes of auditory brainstem responses (ABRs) elicited by 8-kHz tones or (2) EFR amplitudes evoked by sinusoidally amplitude-modulated (SAM) tones at 100% depth. Matched wave I amplitudes across age corresponded to approximately 20-dB sound level differences. For matched wave I, no age-related differences were observed in wave V amplitudes. However, EFRs recorded in silence were enhanced with aging at 100% but not at 25% depth, consistent with enhanced central gain in aging. For matched EFRs, there were no age-related differences in EFRs of amplitude modulation (AM) depth and AM frequency processing. These results suggest novel, objective measures beyond threshold to compensate for differences in auditory nerve activation and to differentiate peripheral and central contributions of EFRs.