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Details

Autor(en) / Beteiligte
Titel
Identification of a novel recombinant virulent avian infectious bronchitis virus
Ist Teil von
  • Veterinary microbiology, 2017-02, Vol.199, p.120-127
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2017
Quelle
MEDLINE
Beschreibungen/Notizen
  • •A novel IBV variant CK/CH/2010/JT-1 was identified.•A novel genotypic cluster IBV has emerged in China.•Isolate CK/CH/2010/JT-1 originated from homologous RNA recombination.•Isolate CK/CH/2010/JT-1 is highly virulent. The emergence of new infectious bronchitis virus (IBV) variants is often disastrous in the poultry industry. In this study, an IBV, CK/CH/2010/JT-1, was isolated from an H120- and 4/91-IBV-vaccinated flock in China. Antisera against vaccine strains H120 and 4/91 could not provide effective protection against CK/CH/2010/JT-1 in virus neutralization assays. CK/CH/2010/JT-1 could cause 43.75% mortality with respiratory and severe renal lesions in inoculated chickens. Phylogenetic analysis of the S1 gene showed that CK/CH/2010/JT-1 and 31 other isolates could be grouped as a new genotypic cluster. Recombination analysis revealed that three recombination events could be found in the genome of CK/CH/2010/JT-1 at positions 24709-365, 17160-19811 and 21136-21770. Whole-genome sequence analysis showed that CK/CH/2010/JT-1 originated from multiple template switches among QX-like, CK/CH/LSC/99I-, tl/CH/LDT3/03- and 4/91-type IBVs. All of these data demonstrated that CK/CH/2010/JT-1 is a new recombinant genotype IBV with high virulence. Our findings suggest that the surveillance of new genotype strains of IBV is very important for developing more effective anti-IBV strategies.

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