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Antibacterial effects of electrospun chitosan/poly(ethylene oxide) nanofibrous membranes loaded with chlorhexidine and silver
Ist Teil von
Nanomedicine, 2016-07, Vol.12 (5), p.1357-1364
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
Abstract To prevent percutaneous device associated infections (PDAIs), we prepared electrospun chitosan/poly(ethylene oxide) (PEO) nanofibrous membrane containing silver nanoparticles as implantable delivery vehicle for the dual release of chlorhexidine and silver ions. We observed that the silver nanoparticles were distributed homogeneously throughout the fibres, and a fast release of chlorhexidine in 2 days and a sustained release of silver ions for up to 28 days. The antibacterial efficacy of the membranes against Staphylococcus aureus showed that the membranes exhibited an obvious inhibition zone upon loading with either chlorhexidine (20 μg or more per membrane) or AgNO3 (1 and 5 wt% to polymer). Furthermore, long term antibacterial effect up to 4 days was verified using membranes containing 5 wt% AgNO3 . The results suggest that the membranes have strong potential to act as active antibacterial dressing for local delivery of antibacterial agents to prevent PDAIs.