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Update on Global Intervention Studies in Type 1 Diabetes
Ist Teil von
Endocrinology and metabolism clinics of North America, 2012-12, Vol.41 (4), p.695-712
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2012
Link zum Volltext
Beschreibungen/Notizen
Remarkable progress has been made in strategies to arrest pancreatic β-cell destruction in type 1 diabetes. Although knowledge of the disease has increased, a safe therapeutic intervention to reverse or prevent it remains elusive. The interaction of genes, immune system, and environment result in a complex disease process that has delayed hopes for a cure. Several well-designed prevention and intervention studies have aspired to test potentially efficacious and safe therapies. This article updates the principles used to design prevention and intervention trials, reviews clinical trials, addresses controversial issues, and provides a framework for future efforts to interdict this condition.