Details

Autor(en) / Beteiligte

• Woodfin, Abigail
• Voisin, Mathieu-Benoit
• Beyrau, Martina
• Colom, Bartomeu
• Caille, Dorothée
• Diapouli, Frantzeska-Maria
• Nash, Gerard B
• Chavakis, Triantafyllos
• Albelda, Steven M
• Rainger, G Ed
• Meda, Paolo
• Imhof, Beat A
• Nourshargh, Sussan

Titel

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

Ist Teil von

• Nature immunology, 2011-08, Vol.12 (8), p.761

Ort / Verlag

United States

Erscheinungsjahr

2011

Link zum Volltext

Beschreibungen/Notizen

• The migration of neutrophils into inflamed tissues is a fundamental component of innate immunity. A decisive step in this process is the polarized migration of blood neutrophils through endothelial cells (ECs) lining the venular lumen (transendothelial migration (TEM)) in a luminal-to-abluminal direction. By real-time confocal imaging, we found that neutrophils had disrupted polarized TEM ('hesitant' and 'reverse') in vivo. We noted these events in inflammation after ischemia-reperfusion injury, characterized by lower expression of junctional adhesion molecule C (JAM-C) at EC junctions, and they were enhanced by blockade or genetic deletion of JAM-C in ECs. Our results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation.