Details

Autor(en) / Beteiligte

• Pecot, Chad V
• Calin, George A
• Coleman, Robert L
• Lopez-Berestein, Gabriel
• Sood, Anil K

Titel

RNA interference in the clinic: challenges and future directions

Ist Teil von

• Nature reviews. Cancer, 2011-01, Vol.11 (1), p.59

Ort / Verlag

England

Erscheinungsjahr

2011

Link zum Volltext

Beschreibungen/Notizen

• Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. Although exploitation of RNAi has immense potential as a cancer therapeutic, many physiological obstacles stand in the way of successful and efficient delivery. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release.