Nature genetics, 2010-06, Vol.42 (6), p.492-494
- Gast, Andreas
- Kinsey, Sally E
- Roman, Eve
- Schrappe, Martin
- Koeffler, H Phillip
- Hosking, Fay J
- Stanulla, Martin
- Sinnett, Daniel
- Harrison, Christine J
- Vijayakrishnan, Jayaram
- Dobbins, Sara E
- Houlston, Richard S
- Zimmermann, Martin
- Erdelyi, Daniel J
- Bartram, Claus R
- Richards, Sue
- Neira, Anna Gonzalez
- Ogawa, Seishi
- Healy, Jasmine
- Hemminki, Kari
- Papaemmanuil, Elli
- Kawamata, Norihiko
- Semsei, Ágnes F
- Irving, Julie A E
- Sherborne, Amy L
- Kumar, Rajiv
- Ma, Yussanne
- Moorman, Anthony V
- Greaves, Mel
- Lightfoot, Tracey
- Koehler, Rolf
- Prasad, Rashmi B
- Taylor, Malcolm
- Szalai, Csaba
- Sheridan, Eamonn
- Allan, James M
- Tomlinson, Ian P
- Krajinovic, Maja
2010
Details
- Autor(en) / Beteiligte
- Gast, Andreas
- Kinsey, Sally E
- Roman, Eve
- Schrappe, Martin
- Koeffler, H Phillip
- Hosking, Fay J
- Stanulla, Martin
- Sinnett, Daniel
- Harrison, Christine J
- Vijayakrishnan, Jayaram
- Dobbins, Sara E
- Houlston, Richard S
- Zimmermann, Martin
- Erdelyi, Daniel J
- Bartram, Claus R
- Richards, Sue
- Neira, Anna Gonzalez
- Ogawa, Seishi
- Healy, Jasmine
- Hemminki, Kari
- Papaemmanuil, Elli
- Kawamata, Norihiko
- Semsei, Ágnes F
- Irving, Julie A E
- Sherborne, Amy L
- Kumar, Rajiv
- Ma, Yussanne
- Moorman, Anthony V
- Greaves, Mel
- Lightfoot, Tracey
- Koehler, Rolf
- Prasad, Rashmi B
- Taylor, Malcolm
- Szalai, Csaba
- Sheridan, Eamonn
- Allan, James M
- Tomlinson, Ian P
- Krajinovic, Maja
- Titel
- Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk
- Ist Teil von
- Nature genetics, 2010-06, Vol.42 (6), p.492-494
- Ort / Verlag
- New York, NY: Nature Publishing Group
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Beschreibungen/Notizen
- Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10−11), irrespective of cell lineage.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.585Titel-ID: cdi_pubmed_primary_20453839
- Format
- –
- Schlagworte
- Acute lymphocytic leukemia, Biological and medical sciences, Case-Control Studies, Cell physiology, Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes, Children, Chromosomes, Human, Pair 9, Colorectal cancer, Data collection, Diagnosis, Fundamental and applied biological sciences. Psychology, Genes, p16, Genetic aspects, Genetic Predisposition to Disease, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Genotype & phenotype, Haplotypes, Health aspects, Hematologic and hematopoietic diseases, Hospitals, Humans, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Medical research, Medical sciences, Molecular and cellular biology, Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics, Project management, Risk factors, Single nucleotide polymorphisms, Studies