Details

Autor(en) / Beteiligte

• Nembhard, Wendy N., PhD
• Wang, Tao, PhD
• Loscalzo, Melissa L., MD
• Salemi, Jason L., MPH

Titel

Variation in the Prevalence of Congenital Heart Defects by Maternal Race/Ethnicity and Infant Sex

Ist Teil von

• The Journal of pediatrics, 2010-02, Vol.156 (2), p.259-264

Ort / Verlag

Maryland Heights, MO: Mosby, Inc

Erscheinungsjahr

2010

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Objective To determine the prevalence of major congenital heart defects (CHD) by ethnicity and sex. Study design Data from the Florida Birth Defects Registry was used to conduct a retrospective cohort study with 8029 singleton infants with 11 CHDs born 1998–2003 to resident non-Hispanic (NH) white, NH-black, and Hispanic women aged 15 to 49. Defect-specific prevalence rates, ratios, and 95% confidence intervals were calculated. Poisson regression was used to calculate adjusted ethnic-specific rate ratios (RR) for each CHD. Statistical significance was P < .0001. Results Compared with NH-whites, NH-black males had significantly increased rates of pulmonary valve atresia/stenosis (RR = 1.66) but lower prevalence of aortic valve atresia/stenosis (RR = 0.33) and ventricular septal defect (VSD; RR = 0.78). Hispanic males had lower rates of aortic valve atresia/stenosis (RR = 0.28), coarctation of the aorta (RR = 0.61) and VSD (RR = 0.79). NH-black females had statistically significantly lower rates of VSD (RR = 0.75), and Hispanic females had lower rates of tetralogy of Fallot (RR = 0.54), VSD (RR = 0.84) and atrioventricular septal defects (RR = 0.53) compared with NH-whites. Conclusions We found differences in ethnic susceptibilities to CHD by sex, but the cause remains unclear.