Details

Autor(en) / Beteiligte

• Gasch, Joanna
• Oertel, Reinhard
• Leopold, Claudia S
• Knoth, Holger

Titel

Contamination of 0.2-micrometer infusion filters by N , N -dimethylacrylamide

Ist Teil von

• Journal of critical care, 2010-03, Vol.25 (1), p.172.e9-172.e14

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Purpose Infusion filters, 0.2 μ m, are commonly used in intensive care units as in-line filters to minimize particle and microbiological burden on patients. These filters usually contain either a positively charged or an uncharged membrane. The aim of the present study was to identify and to quantify an additive causing an unexpected maximum at 234.5 nm in the ultraviolet spectrum of a filtered drug solution using a filter. Materials and Methods For identification and quantification of the substance, water for injection was used as eluent. Measurements were done by mass spectrometry and ultraviolet spectroscopy. Results The unexpected additive in the filter was found to be N , N -dimethylacrylamide. The eluate of 2 filter batches had a mean N , N -dimethylacrylamide concentration of 3.9 and 2.5 μ g/mL, respectively. Further investigations showed that after infusion breaks of different duration, the N , N -dimethylacrylamide concentration at the beginning of the next infusion cycle reaches a higher level than that at the end of the preceding infusion cycle. Conclusions The type of filter examined in this study is primarily used in premature infants, newborns, and infants. These patients are vulnerable to neurotoxic substances having a long-term effect. Therefore, N , N -dimethylacrylamide should be completely removed from the final filter product.