Details

Autor(en) / Beteiligte

• Thaker, Premal H.
• Lutgendorf, Susan K.
• Sood, Anil K.

Titel

The Neuroendocrine Impact of Chronic Stress on Cancer

Ist Teil von

• Cell cycle (Georgetown, Tex.), 2007-02, Vol.6 (4), p.430-433

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2007

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Behavioral processes have long been suspected to influence many health processes including effects on cancer. However, mechanisms underlying these observations are not fully understood. Recent work has demonstrated that chronic behavioral stress results in higher levels of tissue catecholamines, greater tumor burden, and a more invasive pattern of ovarian cancer growth in an orthotopic mouse model. These effects are mediated primarily through the β2 adrenergic receptor (ADRB2) activation of the tumor cell cyclic AMP (cAMP)-protein kinase A (PKA) signaling pathway. Additionally, tumors in stressed animals have increased vascularization and enhanced expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) -2 and -9. In this review, we highlight the importance of the neuroendocrine stress response in tumor biology and discuss mechanisms by which the β-adrenergic receptors on ovarian cancer cells enhance angiogenesis and tumor growth.