Details

Autor(en) / Beteiligte

• Woo, Gye-Hyeong
• Shibutani, Makoto
• Inoue, Kaoru
• Fujimoto, Hitoshi
• Takahashi, Miwa
• Lee, Kyoung-Youl
• Hirose, Masao

Titel

Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay

Ist Teil von

• Food and chemical toxicology, 2007-07, Vol.45 (7), p.1160-1164

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Jamaica quassia extract (JQE), a natural bittering agent, was investigated for hepatocarcinogenesis-promoting potential using a medium-term liver bioassay system. F344 male rats were given a single intraperitoneal injection of diethylnitrosamine (200 mg/kg body weight) and then starting 2 weeks later, received JQE in the diet at concentrations of 500, 5000 or 30,000 ppm for 6 weeks. Animals for tumor promotion (+) and (−) controls were fed 500 ppm sodium phenobarbital (PB) and basal diet, respectively during the promotion phase in this model. All animals were subjected to two-thirds partial hepatectomy at week 3 and killed at week 8. As with the PB-promoted case, both numbers and areas of glutathione S-transferase placental form-positive liver cell foci were significantly increased by JQE at 30,000 ppm, with non-significant increases evident at 5000 ppm. The results thus indicate that JQE at high dose has promoting potential for rat hepatocarcinogenesis.