Autor(en)
Woo, Gye-Hyeong; Shibutani, Makoto; Inoue, Kaoru; Fujimoto, Hitoshi; Takahashi, Miwa; Lee, Kyoung-Youl; Hirose, Masao
Titel
Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay
Teil von
  • Food and chemical toxicology, 2007-07-01, Vol.45 (7), p.1160-1164
Ort / Verlag
OXFORD: PERGAMON-ELSEVIER SCIENCE LTD
Links zum Volltext
Quelle
Web of Science
Beschreibungen
Jamaica quassia extract (JQE), a natural bittering agent, was investigated for hepatocarcinogenesis-promoting potential using a medium-term liver bioassay system. F344 male rats were given a single intraperitoneal injection of diethylnitrosamine (200 mg/kg body weight) and then starting 2 weeks later, received JQE in the diet at concentrations of 500, 5000 or 30,000 ppm for 6 weeks. Animals for tumor promotion (+) and (-) controls were fed 500 ppm sodium phenobarbital (PB) and basal diet, respectively during the promotion phase in this model. All animals were subjected to two-thirds partial hepatectomy at week 3 and killed at week 8. As with the PB-promoted case, both numbers and areas of glutathione S-transferase placental form-positive liver cell foci were significantly increased by JQE at 30,000 ppm, with non-significant increases evident at 5000 ppm. The results thus indicate that JQE at high dose has promoting potential for rat hepatocarcinogenesis. (c) 2007 Elsevier Ltd. All rights reserved.

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX
Die Universität der Informationsgesellschaft