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Dapsone hypersensitivity syndrome masquerading as a viral exanthem: three cases and a mini-review
Ist Teil von
Annals of the Academy of Medicine, Singapore, 2004-05, Vol.33 (3), p.375-378
Ort / Verlag
Singapore
Erscheinungsjahr
2004
Link zum Volltext
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
We report 3 cases of dapsone hypersensitivity syndrome due to anti-malarial chemoprophylactic treatment with maloprim, in military servicemen, presenting like a viral exanthem.
Three male military recruits presented with fever and rash, 6 to 8 weeks after commencing on weekly doses of maloprim.
A course of topical and systemic corticosteroids and oral antihistamines were started.
All cases showed gradual resolution of fever, rash and eventual normalisation of liver function test.
A high index of suspicion was required before this uncommon syndrome can be recognised. Early institution of corticosteroid therapy and discontinuation of maloprim are the mainstays of treatment.