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Risk of Childhood Leukemia and Parental Self-reported Occupational Exposure to Chemicals, Dusts, and Fumes: Results from Pooled Analyses of German Population-based Case-Control Studies
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2000-08, Vol.9 (8), p.835-838
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2000
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
A recent large-scale United States study reported an association between
parental exposure to hydrocarbons at work and the risk of childhood
leukemia. Parental occupational exposure to different chemicals and
industrial dusts or fumes also was assessed in three German
case-control studies that were conducted from 1992–1997. The design
and methods of exposure assessment were similar for these studies;
therefore, they were pooled for this analysis. In total, these
three studies involved 1138 cases of acute lymphocytic leukemia
(ALL) and 2962 controls. We found that maternal exposure to paints or
lacquers during the preconception period (odds ratio, 1.6; 95%
confidence interval, 1.1–2.4) and during the index pregnancy (odds
ratio, 2.0; 95% confidence interval, 1.2–3.3) was related to an
increased risk of childhood ALL. Whereas our findings for exposure to
paints or lacquers confirmed observations from the United States study,
we failed to confirm associations between risk of ALL and maternal
exposure to solvents and parental exposure to plastic materials. Our
studies provide some evidence that parental occupational exposure to
certain substances may be associated with cancer risk in offspring;
however, more specific studies are needed to identify such substances
and the doses that may be hazardous.