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Treatment should focus on the underlying etiology behind these processes The Neuro-Connection While the targets and mechanisms of systemic inflammatory diseases are variable, many of these diseases share similar manifestations in the eye. [...]through the course of these autoimmune conditions, it is imperative to keep in mind the potential ocular ramifications associated with these diseases. In light of these mechanisms, autoimmune disease may be considered a hypercoagulable state, thus explaining why numerous autoimmune diseases such as systemic lupus erythematosus, inflammatory bowel disease, and Behcet's syndrome have been shown to confer a high risk of venous thromboembolism5. Since thrombosis underlies many neuro-ophthalmologic conditions, in patients with symptoms concerning for these pathologies, autoimmunity should be considered as a culprit. [...]in patients with history of autoimmune disease that present with neuro-ophthalmologic signs and symptoms, after pertinent workup, treatment should focus on the underlying etiology behind these processes. Patients with acute neuro-ophthalmic presentations who have active systemic autoimmune disease might require hospital admission, urgent neuroimaging and systemic evaluation, high-dose intravenous corticosteroids, or additional immunosuppressive or disease modifying rheumatologic drugs. 'Since thrombosis underlies many neuro-ophthalmologic conditions, in patients with symptoms concerning for these pathologies, autoimmunity should be considered as a culprit.