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Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer
Journal of surgical oncology, 2011-12, Vol.104 (7), p.734-740
Yoo, Han Mo
Lee, Han Hong
Shim, Jung Ho
Jeon, Hae Myung
Park, Cho Hyun
Song, Kyo Young
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Yoo, Han Mo
Lee, Han Hong
Shim, Jung Ho
Jeon, Hae Myung
Park, Cho Hyun
Song, Kyo Young
Titel
Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer
Ist Teil von
Journal of surgical oncology, 2011-12, Vol.104 (7), p.734-740
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background and Objectives Leakage has been shown to adversely affect survival in patients undergoing surgery for gastrointestinal malignancies. However, the effect of leakage following radical gastrectomy in patients with gastric cancer remains unclear. Methods In total, 478 patients with advanced gastric cancer who underwent surgery with curative intent were reviewed. Anastomosis or duodenal stump leakage was diagnosed clinically or radiologically. Risk factors for leakage were evaluated by univariate and multivariate analyses. The impact of leakage on patient survival was analyzed using the Kaplan–Meier method. Results Leakage was diagnosed in 32 of 478 patients (6.7%); 14 patients (2.9%) exhibited esophagojejunal anastomotic leakage, 14 (2.9%) showed duodenal stump leakage, and four (0.8%) showed gastroduodenal anastomotic leakage. Poor performance status [odds ratio (OR): 4.01, 95% confidence interval (CI): 1.80–8.93] and tumor location (OR: 3.74, 95% CI: 1.56–8.89) were risk factors for postoperative leakage. Overall mean survival of patients with leakage was significantly lower than that of patients without leakage (30.5 vs. 96.2 months; P < 0.001). Leakage was one of the independent predictive factor for overall survival [hazard ratio (HR): 3.58, 95% CI: 2.29–5.59]. Conclusions Postoperative inflammation due to leakage is a negative prognostic factor for patients with advanced gastric cancer. J. Surg. Oncol. 2011; 104:734–740. © 2011 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0022-4790
eISSN: 1096-9098
DOI: 10.1002/jso.22045
Titel-ID: cdi_proquest_miscellaneous_901642352
Format
–
Schlagworte
advanced gastric cancer
,
Anastomosis, Surgical - adverse effects
,
Anastomosis, Surgical - methods
,
Anastomotic Leak - epidemiology
,
Anastomotic Leak - mortality
,
curative surgery
,
Female
,
Gastrectomy
,
Humans
,
inflammation
,
Korea - epidemiology
,
leakage
,
Logistic Models
,
Male
,
Middle Aged
,
Multivariate Analysis
,
Prevalence
,
Proportional Hazards Models
,
Prospective Studies
,
Risk Factors
,
Stomach Neoplasms - mortality
,
Stomach Neoplasms - surgery
,
survival
,
Survival Rate
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