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Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians
Acta neurologica Scandinavica, 2011-10, Vol.124 (4), p.264-268
Wu, Y.-w.
Rong, T.-y.
Li, H.-H.
Xiao, Q.
Fei, Q.-z.
Tan, E.-K.
Ding, J.-q.
Chen, S.-d.
2011
Details
Autor(en) / Beteiligte
Wu, Y.-w.
Rong, T.-y.
Li, H.-H.
Xiao, Q.
Fei, Q.-z.
Tan, E.-K.
Ding, J.-q.
Chen, S.-d.
Titel
Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians
Ist Teil von
Acta neurologica Scandinavica, 2011-10, Vol.124 (4), p.264-268
Ort / Verlag
Oxford, UK: Blackwell Publishing Ltd
Erscheinungsjahr
2011
Link zum Volltext
Quelle
EBSCOhost Psychology and Behavioral Sciences Collection
Beschreibungen/Notizen
Wu Y‐w, Rong T‐y, Li H‐H, Xiao Q, Fei Q‐z, Tan E‐K, Ding J‐q, Chen S‐d. Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians. Acta Neurol Scand: 2011: 124: 264–268. © 2010 John Wiley & Sons A/S. Objective – Genome‐wide association study (GWAS) has identified a variant in LINGO1 (rs9652490) that increases the risk of essential tremor (ET) among Caucasians. It has been suggested that among Asians, the risk variant is relevant only for the familial forms of ET. We investigated the association of the rs9652490 variant with sporadic and familial ET in a Chinese population and conducted a pooled analysis to compare the potential differential effect between sporadic and familial ET. Methods – rs9652490 was genotyped by direct sequencing in 117 ET and 160 controls in a Chinese population. Previous published data from another Asian population were included in the meta‐analysis. Result – There were no significant differences in the minor allele frequency and genotype frequency between ET and controls in our Chinese population. However, in the pooled analysis involving 1201 subjects, patients with ET had a higher proportion of GG genotype compared to controls. Logistic regression analysis revealed that G allele increased the risk of ET via a recessive model. In both familial ET and sporadic ET, the G allele increased the risk via a recessive model. Conclusion – While we could not demonstrate a significant association of the rs9652490 variant in our own study, pooled analysis of a much larger cohort revealed for the first time that the variant increased the risk in both familial and sporadic forms of ET among Asians, though the effect was stronger in familial ET.
Sprache
Englisch
Identifikatoren
ISSN: 0001-6314
eISSN: 1600-0404
DOI: 10.1111/j.1600-0404.2010.01466.x
Titel-ID: cdi_proquest_miscellaneous_901002855
Format
–
Schlagworte
Aged
,
Aged, 80 and over
,
Alleles
,
Asian Continental Ancestry Group - genetics
,
Asian sample
,
Case-Control Studies
,
Data processing
,
essential tremor
,
Essential Tremor - ethnology
,
Essential Tremor - genetics
,
Female
,
Gene frequency
,
Gene Pool
,
Genetic Predisposition to Disease
,
Genome-Wide Association Study
,
Genotype
,
Genotypes
,
Hospitals, Teaching
,
Humans
,
LINGO1
,
Logistic Models
,
Male
,
Membrane Proteins - genetics
,
meta-analysis
,
Middle Aged
,
Nerve Tissue Proteins - genetics
,
Polymorphism, Single Nucleotide - genetics
,
Population genetics
,
Population Surveillance
,
Regression analysis
,
Reviews
,
Risk
,
tremor
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