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BibTeX
Genome-wide association study in German patients with attention deficit/hyperactivity disorder
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2011-12, Vol.156B (8), p.888-897
Hinney, Anke
Scherag, André
Jarick, Ivonne
Albayrak, Özgür
Pütter, Carolin
Pechlivanis, Sonali
Dauvermann, Maria R.
Beck, Sebastian
Weber, Heike
Scherag, Susann
Nguyen, Trang T.
Volckmar, Anna-Lena
Knoll, Nadja
Faraone, Stephen V.
Neale, Benjamin M.
Franke, Barbara
Cichon, Sven
Hoffmann, Per
Nöthen, Markus M.
Schreiber, Stefan
Jöckel, Karl-Heinz
Wichmann, H.-Erich
Freitag, Christine
Lempp, Thomas
Meyer, Jobst
Gilsbach, Susanne
Herpertz-Dahlmann, Beate
Sinzig, Judith
Lehmkuhl, Gerd
Renner, Tobias J.
Warnke, Andreas
Romanos, Marcel
Lesch, Klaus-Peter
Reif, Andreas
Schimmelmann, Benno G.
Hebebrand, Johannes
2011
Details
Autor(en) / Beteiligte
Hinney, Anke
Scherag, André
Jarick, Ivonne
Albayrak, Özgür
Pütter, Carolin
Pechlivanis, Sonali
Dauvermann, Maria R.
Beck, Sebastian
Weber, Heike
Scherag, Susann
Nguyen, Trang T.
Volckmar, Anna-Lena
Knoll, Nadja
Faraone, Stephen V.
Neale, Benjamin M.
Franke, Barbara
Cichon, Sven
Hoffmann, Per
Nöthen, Markus M.
Schreiber, Stefan
Jöckel, Karl-Heinz
Wichmann, H.-Erich
Freitag, Christine
Lempp, Thomas
Meyer, Jobst
Gilsbach, Susanne
Herpertz-Dahlmann, Beate
Sinzig, Judith
Lehmkuhl, Gerd
Renner, Tobias J.
Warnke, Andreas
Romanos, Marcel
Lesch, Klaus-Peter
Reif, Andreas
Schimmelmann, Benno G.
Hebebrand, Johannes
Titel
Genome-wide association study in German patients with attention deficit/hyperactivity disorder
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2011-12, Vol.156B (8), p.888-897
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
The heritability of attention deficit hyperactivity disorder (ADHD) is approximately 0.8. Despite several larger scale attempts, genome‐wide association studies (GWAS) have not led to the identification of significant results. We performed a GWAS based on 495 German young patients with ADHD (according to DSM‐IV criteria; Human660W‐Quadv1; Illumina, San Diego, CA) and on 1,300 population‐based adult controls (HumanHap550v3; Illumina). Some genes neighboring the single nucleotide polymorphisms (SNPs) with the lowest P‐values (best P‐value: 8.38 × 10−7) have potential relevance for ADHD (e.g., glutamate receptor, metabotropic 5 gene, GRM5). After quality control, the 30 independent SNPs with the lowest P‐values (P‐values ≤ 7.57 × 10−5) were chosen for confirmation. Genotyping of these SNPs in up to 320 independent German families comprising at least one child with ADHD revealed directionally consistent effect‐size point estimates for 19 (10 not consistent) of the SNPs. In silico analyses of the 30 SNPs in the largest meta‐analysis so far (2,064 trios, 896 cases, and 2,455 controls) revealed directionally consistent effect‐size point estimates for 16 SNPs (11 not consistent). None of the combined analyses revealed a genome‐wide significant result. SNPs in previously described autosomal candidate genes did not show significantly lower P‐values compared to SNPs within random sets of genes of the same size. We did not find genome‐wide significant results in a GWAS of German children with ADHD compared to controls. The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD. © 2011 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841, 1552-485X
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.31246
Titel-ID: cdi_proquest_miscellaneous_900634067
Format
–
Schlagworte
Adolescent
,
Adult
,
Attention Deficit Disorder with Hyperactivity - genetics
,
Attention deficit hyperactivity disorder
,
Biological and medical sciences
,
Child
,
Children
,
copy number
,
early onset
,
Female
,
Genetic Markers
,
Genome-Wide Association Study
,
Genotype
,
Genotyping
,
Germany
,
Glutamic acid receptors
,
Glutamic acid receptors (metabotropic)
,
Heritability
,
homogeneous
,
Humans
,
Introns
,
Male
,
Medical genetics
,
Medical sciences
,
Polymorphism, Single Nucleotide
,
psychiatric
,
Quality control
,
Receptor, Metabotropic Glutamate 5
,
Receptors, Metabotropic Glutamate - genetics
,
Reviews
,
Single-nucleotide polymorphism
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