Autor(en)
Xue, Fei; Luo, Xianjin; Ye, Chenghao; Ye, Weidong; Wang, Yue
Titel
Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses
Teil von
  • Bioorganic & medicinal chemistry, 2011-04-15, Vol.19 (8), p.2641-2649
Ort / Verlag
OXFORD: PERGAMON-ELSEVIER SCIENCE LTD
Links zum Volltext
Quelle
ScienceDirect Journals (5 years ago - present)
Beschreibungen
A series of novel benzimidazole derivatives were designed, synthesized, and evaluated for their activities against four kinds of enteroviruses, that is, Coxsackie virus A16, B3, B6 and Enterovirus 71 in VERO cells. Strong activities against enterovirus replication and low cytotoxicities were observed in these benzimidazoles generally. The most promising compound was (L)-2-(pyridin-2-yl)-N-(2-(4-nitrophenyl)pentan-3-yl)-1H-benzimidazole-4-carboxamide (16), with a high antiviral potency (IC50 = 1.76 mu g/mL) and a remarkable selectivity index (328). These compounds were selected for further evaluation as novel enterovirus inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.

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