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BAFF production by antigen‐presenting cells provides T cell co‐stimulation
Ist Teil von
International immunology, 2004-03, Vol.16 (3), p.467-475
Ort / Verlag
England: Oxford University Press
Erscheinungsjahr
2004
Link zum Volltext
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
The B cell‐activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co‐stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co‐stimulatory function. BAFF is produced by antigen‐presenting cells (APC). Blood dendritic cells (DC) as well as DC differentiated in vitro from monocytes or CD34+ stem cells express BAFF mRNA. Exposure to bacterial products further up‐regulates BAFF production in these cells. A low level of BAFF transcription, up‐regulated upon TCR stimulation, was also detected in T cells. Functionally, blockade of endogenous BAFF produced by APC and, to a lesser extent, by T cells inhibits T cell activation. Altogether, this indicates that BAFF may regulate T cell immunity during APC–T cell interactions and as an autocrine factor once T cells have detached from the APC.