Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Effects of oxygen inhalation on tissue oxygenation in patients with cirrhosis: Evidence for an impaired arterial baroreflex control
Ist Teil von
Journal of hepatology, 1989-09, Vol.9 (2), p.240-245
Ort / Verlag
Oxford: Elsevier B.V
Erscheinungsjahr
1989
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
In patients with cirrhosis, O
2 uptake, i.e., O
2 consumption, is abnormally decreased. We administered 50% O
2 for 30 min in eight patients with alcoholic cirrhosis to determine whether the subsequent increase in arterial O
2 content may correct the low O
2 consumption. In addition, we studied in these patients the reflex control of cardiac output and blood pressure by arterial baroreceptors, as O
2 inhalation induces a systemic vasoconstriction. Arterial O
2 tension, oxyhaemoglobin saturation and arterial O
2 content significantly increased as well as systemic vascular resistance and arterial pressure. In contrast, O
2 consumption (which was below normal values) under basal conditions, O
2 transport, O
2 extraction ratio, heart rate, right atrial and pulmonary wedged pressures, cardiac output, hepatic venous pressures, hepatic and azygos blood flows were unaffected by O
2 administration. In three patients receiving air, no significant change was observed. Our results show that, in patients with cirrhosis, inhalation of 50% O
2 does not correct O
2 consumption. We may conclude that reflex control of cardiac output and arterial pressure by arterial baroreceptors is impaired in these patients.