FEBS letters, 1997-05, Vol.408 (3), p.289-291
1997
Details
- Autor(en) / Beteiligte
- Titel
- Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts
- Ist Teil von
- FEBS letters, 1997-05, Vol.408 (3), p.289-291
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 1997
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Ultraviolet A (UVA: 320–400 nm) radiation activates c-Jun–N-terminal kinase (JNK 2) in human skin fibroblasts. Exposure of cells to UVA (300 kJ/m 2) led to a 5-fold induction of JNK-activity which was significantly increased in the presence of D 2O, an enhancer of the lifetime of singlet oxygen. Sodium azide, a quencher of singlet oxygen, abolished the activation of JNK. A hydroxyl radical scavenger, mannitol, had no effect. Furthermore, photochemically produced singlet oxygen (Rose Bengal plus white light) was found to induce JNK activity. This was enhanced by D 2O and inhibited by azide. Thus, singlet oxygen activates and mediates the UVA-induced activation of JNK.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/S0014-5793(97)00440-7Titel-ID: cdi_proquest_miscellaneous_79065967
- Format
- –
- Schlagworte
- c-Jun–amino-terminal kinase, c-Jun–N-terminal kinase, Calcium-Calmodulin-Dependent Protein Kinases - biosynthesis, Calcium-Calmodulin-Dependent Protein Kinases - metabolism, Cells, Cultured, Enzyme Induction - radiation effects, Fibroblasts - metabolism, Fibroblasts - radiation effects, Free Radical Scavengers - pharmacology, Human skin fibroblast, Humans, JNK, JNK Mitogen-Activated Protein Kinases, Kinetics, Light, Male, Mannitol - pharmacology, Mitogen-Activated Protein Kinases, Models, Biological, Oxygen - metabolism, Rose Bengal, Rose Bengal - pharmacology, Singlet Oxygen, Skin - radiation effects, ultraviolet A radiation (320–400 nm), Ultraviolet Rays, UVA