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Optical and FDG mapping of frequency-specific activity in auditory cortex
Ist Teil von
Neuroreport, 1996-11, Vol.7 (15-17), p.2643-2647
Ort / Verlag
Hagerstown, MD: Lippincott Williams and Wilkins
Erscheinungsjahr
1996
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
With optical recording of intrinsic signals (ORIS) and tone stimulation, we analysed frequency- and intensity-dependent spatio-temporal activity in primary auditory cortex AE of awake Mongolian gerbils. We found a two-dimensional and assymetric propagation of ORIS activity (1) from ventral to dorsal along isofrequency contours at all frequencies and (2) from the low-frequency end across the complete tonotopic gradient at low frequencies. High-frequency representations remained tonotopic. Tonotopic asymmetries were independent of stimulus intensity. By contrast, in fluoro-2-deoxyglucose images from the same animals metabolic activity was tonotopically confined at high and low frequencies. The assymetric tonotopic propagation of ORIS activity suggests subthreshold directional interaction mechanisms in the cortical network which may serve to relate low- to high-frequency components of complex sounds.