Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Modulation of the escape response by [ d-Ala 2]Met-enkephalin in the crab Chasmagnathus
Ist Teil von
Pharmacology, biochemistry and behavior, 1995-03, Vol.50 (3), p.445-451
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
1995
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
The synthetic opioid analog [
d-Ala
2]Met-enkephalin (DAME) significantly reduces the escape response to a danger stimulus in the crab
Chasmagnathus granulatus when administered within the dose range 0.01–1.0 μg/g. There is no reduction with lower or higher doses, thus suggesting a U-shaped dose-response curve. A 0.1-μg/g dose of naloxone has no effect per se on the response, but when it is administered together with DAME, it completely blocks the decrementai effect of this drug and an escape response generally higher than that of control is observed. An explanation for these results in terms of a possible dual action of DAME is offered. In addition, we present evidence for different degrees of opiate sensitivity among crabs of the same population in relation to their different degrees of reactivity to the visual danger stimulus.