Details

Autor(en) / Beteiligte

• Lin, Anning
• Minden, Audrey
• Martinetto, Horacio
• Claret, Francois-Xavier
• Lange-Carter, Carol
• Mercurio, Frank
• Johnson, Gary L.
• Karin, Michael

Titel

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

Ist Teil von

• Science (American Association for the Advancement of Science), 1995-04, Vol.268 (5208), p.286-290

Ort / Verlag

Washington, DC: American Society for the Advancement of Science

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• One Ras-dependent protein kinase cascade leading from growth factor receptors to the ERK (extracellular signal-regulated kinases) subgroup of mitogen-activated protein kinases (MAPKs) is dependent on the protein kinase Raf-1, which activates the MEK (MAPK or ERK kinase) dual specificity kinases. A second protein kinase cascade leading to activation of the Jun kinases (JNKs) is dependent on MEKK (MEK kinase). A dual-specificity kinase that activates JNK, named JNKK, was identified that functions between MEKK and JNK. JNKK activated the JNKs but did not activate the ERKs and was unresponsive to Raf-1 in transfected HeLa cells. JNKK also activated another MAPK, p38 (Mpk2; the mammalian homolog of HOG1 from yeast), whose activity is regulated similarly to that of the JNKs.