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The Effects of Tissue Plasminogen Activator, Streptokinase, or Both on Coronary-Artery Patency, Ventricular Function, and Survival after Acute Myocardial Infarction
Ist Teil von
The New England journal of medicine, 1993-11, Vol.329 (22), p.1615-1622
Ort / Verlag
Boston, MA: Massachusetts Medical Society
Erscheinungsjahr
1993
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
The hypothesis that more rapid restoration of flow through the infarct-related artery after the initiation of thrombolytic therapy may better preserve left ventricular function and improve survival among patients with acute myocardial infarction has been controversial. The recently reported Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) trial
1
demonstrated that improved survival was associated with the administration of recombinant tissue plasminogen activator (t-PA) in an accelerated dosing schedule known to produce rapid reperfusion, as compared with streptokinase, which is believed to be a slower activator. In contrast, two previous large studies, those of the Gruppo . . .