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Non‐CLL‐like monoclonal B‐cell lymphocytosis in the general population: Prevalence and phenotypic/genetic characteristics
Cytometry. Part B, Clinical cytometry, 2010, Vol.78B (S1), p.S24-S34
Nieto, Wendy G.
Teodosio, Cristina
López, Antonio
Rodríguez‐Caballero, Arancha
Romero, Alfonso
Bárcena, Paloma
Gutierrez, Maria Laura
Langerak, Anton W.
Fernandez‐Navarro, Paulino
Orfao, Alberto
Almeida, Julia
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Nieto, Wendy G.
Teodosio, Cristina
López, Antonio
Rodríguez‐Caballero, Arancha
Romero, Alfonso
Bárcena, Paloma
Gutierrez, Maria Laura
Langerak, Anton W.
Fernandez‐Navarro, Paulino
Orfao, Alberto
Almeida, Julia
Titel
Non‐CLL‐like monoclonal B‐cell lymphocytosis in the general population: Prevalence and phenotypic/genetic characteristics
Ist Teil von
Cytometry. Part B, Clinical cytometry, 2010, Vol.78B (S1), p.S24-S34
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Background: Monoclonal B‐cell lymphocytosis (MBL) indicates <5 × 109 peripheral blood (PB) clonal B‐cells/L in healthy individuals. In most cases, MBL cells show similar phenotypic/genetic features to chronic lymphocytic leukemia cells—CLL‐like MBL—but little is known about non‐CLL‐like MBL. Methods: PB samples from 639 healthy individuals (46% men/54% women) >40 years old (62 ± 13years) with normal lymphocyte counts (2.1 ± 0.7 × 109/L) were immunophenotyped using high‐sensitive flow cytometry, based on 8‐color stainings and the screening for >5 × 106 total PB leukocytes. Results: Thirteen subjects (2.0%; 9 males/4 females, aged 73 ± 10 years; absolute lymphocyte count: 2.4 ± 0.8 × 109/L) showed a non‐CLL‐like clonal B‐cell population, whose frequency clearly increased with age: 0.4%, 3%, and 5.4% of subjects aged 40–59, 60–79, and ≥80 years, respectively. One single B‐cell clone was detected in 9/13 cases, while two B‐cell clones were found in 4/13 (n = 17 MBL populations). Nine MBL cell populations showed a CD5− phenotype (usually overlapping with marginal zone‐derived (MZL) or lymphoplasmacytic (LPL) non‐Hodgkin lymphoma (NHL) B‐cells, or an unclassifiable NHL), but CD5−/+d (n = 3) and CD5+ (n = 3 non‐CLL‐like MBL, consistent with a mantle‐cell lymphoma (MCL)‐like phenotype, and n = 2 CLL‐like) MBL were also identified; iFISH supported the diagnosis in most cases. No preferential IGHV usage of B‐cell receptor could be found. Twelve cases reevaluated at month +12 showed circulating clonal B‐cells, at mean levels significantly higher than those initially detected. Conclusions: Non‐CLL‐like MBL cases frequently show biclonality, in association with MZL‐, LPL‐, MCL‐like, or unclassifiable phenotypic profiles. As with CLL‐like MBL, the frequency of non‐CLL‐like MBL increases with age, with a clear predominance of males. © 2010 International Clinical Cytometry Society
Sprache
Englisch
Identifikatoren
ISSN: 1552-4949, 1552-4957
eISSN: 1552-4957
DOI: 10.1002/cyto.b.20543
Titel-ID: cdi_proquest_miscellaneous_755188696
Format
–
Schlagworte
Adult
,
Age
,
Age Factors
,
Aged
,
Aged, 80 and over
,
B-Lymphocytes - immunology
,
B-Lymphocytes - pathology
,
Cell number
,
Chronic lymphatic leukemia
,
chronic lymphocytic leukemia
,
CLL
,
Clone Cells
,
double prime B-cell receptor
,
Female
,
Flow cytometry
,
Gene Rearrangement, B-Lymphocyte
,
Humans
,
Immunoglobulin Heavy Chains - genetics
,
Immunophenotyping
,
In Situ Hybridization, Fluorescence
,
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
,
Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology
,
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
,
Leukemia, Lymphocytic, Chronic, B-Cell - immunology
,
Leukocytes
,
Lymphocyte Count
,
Lymphocytes B
,
Lymphocytosis
,
Lymphocytosis - diagnosis
,
Lymphocytosis - epidemiology
,
Lymphocytosis - genetics
,
Lymphocytosis - immunology
,
Lymphoma
,
Male
,
MBL
,
Middle Aged
,
monoclonal B‐cell lymphocytosis
,
non‐CLL‐like MBL
,
Peripheral blood
,
Phenotype
,
Prevalence
,
Sex Factors
,
Spain - epidemiology
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