Nature (London), 2010-07, Vol.466 (7302), p.118-122
2010
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- Autor(en) / Beteiligte
- Titel
- The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
- Ist Teil von
- Nature (London), 2010-07, Vol.466 (7302), p.118-122
- Ort / Verlag
- London: Nature Publishing Group
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Various social behaviours in mice are regulated by chemical signals called pheromones that act through the vomeronasal system. Exocrine gland-secreting peptide 1 (ESP1) is a 7-kDa peptide that is released into male tear fluids and stimulates vomeronasal sensory neurons in female mice. Here, we describe the molecular and neural mechanisms that are involved in the decoding of ESP1 signals in the vomeronasal system, which leads to behavioural output in female mice. ESP1 is recognized by a specific vomeronasal receptor, V2Rp5, and the ligand-receptor interaction results in sex-specific signal transmission to the amygdaloid and hypothalamic nuclei via the accessory olfactory bulb. Consequently, ESP1 enhances female sexual receptive behaviour upon male mounting (lordosis), allowing successful copulation. In V2Rp5-deficient mice, ESP1 induces neither neural activation nor sexual behaviour. These findings show that ESP1 is a crucial male pheromone that regulates female reproductive behaviour through a specific receptor in the mouse vomeronasal system.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/nature09142Titel-ID: cdi_proquest_miscellaneous_746012209
- Format
- –
- Schlagworte
- Animal and plant ecology, Animal ethology, Animal, plant and microbial ecology, Animals, Artificial chromosomes, Autoecology, Behavior, Behavioural, Biological and medical sciences, Brain - cytology, Brain - metabolism, Bulbs, Female, Females, Fundamental and applied biological sciences. Psychology, Genetic aspects, Male, Males, Mammalia, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Neurons, Neurons - metabolism, Peptides, Pheromones, Pheromones - metabolism, Physiological aspects, Proteins - metabolism, Proto-Oncogene Proteins c-fos - metabolism, Psychology. Psychoanalysis. Psychiatry, Receptors, Receptors, Odorant - deficiency, Receptors, Odorant - genetics, Receptors, Odorant - metabolism, Receptors, Pheromone - deficiency, Receptors, Pheromone - genetics, Receptors, Pheromone - metabolism, Rodents, Sensory receptors, Sex, Sexual Behavior, Animal - physiology, TRPC Cation Channels - deficiency, Vertebrata, Vomeronasal Organ - cytology, Vomeronasal Organ - innervation, Vomeronasal Organ - metabolism