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One of the possibilities for estimating pancreas activity is the estimation of zymogene granule content in pancreatic follicular cells. In the present study, the degree of pancreatic activity was measured in piglets from sows receiving enzymatic stimulating complex throughout pregnancy and during the lactation period. The pancreas was collected for ultrastructural examination from 1-day-old and 21-day-old piglets. The enzyme preparation influenced the ultrastructural structure of the piglet pancreas, but the secretory cells in these animals did not confirm a more intensive course of creation and maturation processes. The accumulation of granules in extra-secretory pancreatic cells was observed, with a large volume of these granules and granular crinophagy observed in older piglets. The findings indicate a slow process of granule release, which may be the result of overproduction, lower requirements for enzymes contained in the granules, or both.