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Macrophage infiltration into the rat knee detected by MRI in a model of antigen-induced arthritis
Magnetic resonance in medicine, 2003-06, Vol.49 (6), p.1047-1055
Beckmann, Nicolau
Falk, Regina
Zurbrügg, Stefan
Dawson, Janet
Engelhardt, Petra
2003
Details
Autor(en) / Beteiligte
Beckmann, Nicolau
Falk, Regina
Zurbrügg, Stefan
Dawson, Janet
Engelhardt, Petra
Titel
Macrophage infiltration into the rat knee detected by MRI in a model of antigen-induced arthritis
Ist Teil von
Magnetic resonance in medicine, 2003-06, Vol.49 (6), p.1047-1055
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
Three‐dimensional (3D) MR images were obtained from the knees of rats in a model of antigen‐induced arthritis, elicited by the intraarticular administration of methylated bovine serum albumin (mBSA) to previously immunized rats. Superparamagnetic particles of iron oxide (SPIO) were administered i.v. 24 hr before each imaging session. Starting 4 days postantigen injection, images from arthritic knees exhibited distinctive signal attenuation in the synovium. This signal attenuation was significantly smaller in knees from animals treated with dexamethasone, a glucocorticosteroid, and completely absent in contralateral knees that had been challenged with vehicle. A significant negative correlation was found between the MRI signal intensity in the synovium and the histologically determined iron content in macrophages located in the same region. These results suggest the feasibility of detecting macrophage infiltration into the knee synovium in this model of antigen‐induced arthritis by labeling the cells with SPIO. This readout could provide an early marker of disease progression, before more aggressive changes like cartilage and bone erosion take place. Monitoring early changes associated with arthritis can have an impact in preclinical studies by shortening the duration of the experimental period and by facilitating the investigation of novel immunomodulatory therapies acting on macrophages. Also, the approach can be potentially adapted to clinical studies. Magn Reson Med 49:1047–1055, 2003. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.10480
Titel-ID: cdi_proquest_miscellaneous_73323114
Format
–
Schlagworte
Animals
,
Anti-Inflammatory Agents - therapeutic use
,
arthritis
,
Arthritis, Experimental - diagnosis
,
Arthritis, Experimental - drug therapy
,
Arthritis, Experimental - etiology
,
Arthritis, Experimental - immunology
,
Biological and medical sciences
,
Cell Count
,
cell labeling
,
cell tracking
,
dexamethasone
,
Dexamethasone - therapeutic use
,
Disease Models, Animal
,
Female
,
Ferric Compounds
,
Hindlimb - pathology
,
inflammation
,
macrophages
,
Macrophages - metabolism
,
Magnetic Resonance Imaging
,
Medical sciences
,
MRI
,
Rats
,
Rats, Inbred Lew
,
rheumatoid arthritis
,
Serum Albumin, Bovine
,
superparamagnetic particles of iron oxide (SPIO)
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