Fertility and sterility, 2010-05, Vol.93 (8), p.2754-2756
2010
Details
- Autor(en) / Beteiligte
- Titel
- Impaired sperm aggregation in Adam2 and Adam3 null mice
- Ist Teil von
- Fertility and sterility, 2010-05, Vol.93 (8), p.2754-2756
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals Complete
- Beschreibungen/Notizen
- Previous studies have shown that sperm from Adam2 and Adam3 knockout mice have defective migration in the female reproductive tracts and cannot bind to the egg's zona pellucida (ZP), which leads to infertility. Here, we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation, suggesting the requirement of ADAM2 and ADAM3 in normal sperm association.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0015-0282eISSN: 1556-5653DOI: 10.1016/j.fertnstert.2010.03.013Titel-ID: cdi_proquest_miscellaneous_733182956
- Format
- –
- Schlagworte
- A disintegrin and metalloprotease, ADAM Proteins - deficiency, Animals, Biological and medical sciences, Cell Aggregation - physiology, Female, Fertilins, Gynecology. Andrology. Obstetrics, Internal Medicine, knockout, Male, Medical sciences, Membrane Glycoproteins - deficiency, Mice, Mice, Knockout, Obstetrics and Gynecology, sperm association, sperm grouping, Spermatozoa - metabolism, Spermatozoa - physiology, Zona Pellucida - metabolism