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Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines
International journal of cancer, 2004-06, Vol.110 (3), p.352-361
Welsh, Carey
Day, Roger
McGurk, Claire
Masters, John R.W.
Wood, Richard D.
Köberle, Beate
2004
Details
Autor(en) / Beteiligte
Welsh, Carey
Day, Roger
McGurk, Claire
Masters, John R.W.
Wood, Richard D.
Köberle, Beate
Titel
Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines
Ist Teil von
International journal of cancer, 2004-06, Vol.110 (3), p.352-361
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2004
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
Over 80% of patients with advanced metastatic testis tumors can be cured using cisplatin‐based combination chemotherapy. This is unusual as metastatic cancer in adults is usually incurable. Cell lines derived from testis tumors retain sensitivity to cisplatin in vitro. We previously investigated 2 testis tumor cell lines with a low capacity to remove cisplatin‐induced DNA damage and found that they had low levels of the DNA nucleotide excision repair proteins XPA, ERCC1 and XPF. To determine whether low levels of XPA, ERCC1 and XPF proteins are characteristic of testis tumor cell lines, we investigated 35 cell lines derived from cancers to determine whether groups of cell lines from diverse tissue origins differ from one another in constitutive levels of these NER proteins. Quantitative immunoblotting was used to compare groups of cell lines representing prostate, bladder, breast, lung, cervical, ovarian and testis cancers. Only the 6 testis tumor cell lines showed significantly lower mean levels of XPA (p = 0.001), XPF (p = 0.001) and ERCC1 (p = 0.004) proteins from the other groups. Our results encourage further investigation of the possibility that low levels of these nucleotide excision repair proteins could be related to the favorable response of testis tumors to cisplatin‐based chemotherapy. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.20134
Titel-ID: cdi_proquest_miscellaneous_71841329
Format
–
Schlagworte
Biological and medical sciences
,
Cell Line, Tumor
,
DNA Repair
,
DNA repair protein
,
DNA-Binding Proteins - biosynthesis
,
Dose-Response Relationship, Drug
,
Electrophoresis, Polyacrylamide Gel
,
Endonucleases - biosynthesis
,
ERCC1
,
Female
,
Gynecology. Andrology. Obstetrics
,
Humans
,
Immunoblotting
,
Least-Squares Analysis
,
Male
,
Male genital diseases
,
Medical sciences
,
Neoplasm Metastasis
,
Testicular Neoplasms - drug therapy
,
Testis - metabolism
,
testis tumor cell line
,
Tumors
,
Xeroderma Pigmentosum Group A Protein
,
XPA
,
XPF
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