Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1907-1910
2001
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Details
- Autor(en) / Beteiligte
- Titel
- 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1907-1910
- Ort / Verlag
- Oxford: Elsevier
- Erscheinungsjahr
- 2001
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- This communication reports SARs for the first orexin-1 receptor antagonist series of 1-aryl-3-quinolin-4-yl and 1-aryl-3-naphthyridin-4-yl ureas. One of these compounds, 31 (SB-334867), has excellent selectivity for the orexin-1 receptor, blood-brain barrier permeability and shows in vivo activity following ip dosing.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/s0960-894x(01)00343-2Titel-ID: cdi_proquest_miscellaneous_71011886
- Format
- –
- Schlagworte
- Animals, Benzoxazoles - chemical synthesis, Benzoxazoles - pharmacology, Biological and medical sciences, Blood-Brain Barrier, Central Nervous System - metabolism, CHO Cells, Cricetinae, Humans, Indoles - chemistry, Infusions, Intravenous, Medical sciences, Naphthyridines - chemical synthesis, Naphthyridines - pharmacokinetics, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Orexin Receptors, Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems, Permeability, Pharmacology. Drug treatments, Quinolines - chemistry, Receptors, G-Protein-Coupled, Receptors, Neuropeptide - antagonists & inhibitors, Sensitivity and Specificity, Structure-Activity Relationship, Urea - analogs & derivatives, Urea - chemical synthesis, Urea - pharmacology