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Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease
Ist Teil von
Journal of medical genetics, 2008-02, Vol.45 (2), p.114-116
Ort / Verlag
London: BMJ Publishing Group Ltd
Erscheinungsjahr
2008
Link zum Volltext
Quelle
BMJ Journals Archiv - DFG Nationallizenzen
Beschreibungen/Notizen
Background:Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD).Objective and methods:To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case–control dataset.Results:The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes.Conclusions:These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders.