Details

Autor(en) / Beteiligte

• Abdulla, Salim
• Oberholzer, Rolf
• Juma, Omar
• Kubhoja, Sulende
• Machera, Francisca
• Membi, Christopher
• Omari, Said
• Urassa, Alwisa
• Mshinda, Hassan
• Jumanne, Ajuza
• Salim, Nahya
• Shomari, Mwanjaa
• Aebi, Thomas
• Schellenberg, David M
• Carter, Terrell
• Villafana, Tonya
• Demoitié, Marie-Ange
• Dubois, Marie-Claude
• Leach, Amanda
• Lievens, Marc
• Vekemans, Johan
• Cohen, Joe
• Ballou, W. Ripley
• Tanner, Marcel

Titel

Safety and Immunogenicity of RTS,S/AS02D Malaria Vaccine in Infants

Ist Teil von

• The New England journal of medicine, 2008-12, Vol.359 (24), p.2533-2544

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this double-blind study of 340 infants in Tanzania, the candidate malaria vaccine RTS,S/AS02D was compared with the hepatitis B vaccine and coadministered with the standard infant vaccines. No safety concerns were identified, and the immune responses to the coadministered vaccine antigens (diphtheria, tetanus, pertussis, and Haemophilus influenzae type b) were noninferior. In this study of infants in Tanzania, the candidate malaria vaccine RTS,S/AS02D was compared with the hepatitis B vaccine and coadministered with the standard infant vaccines. No safety concerns were identified, and the immune responses to the coadministered vaccine antigens were noninferior. Malaria persists as a major public health problem, and new tools for control of the disease are needed to facilitate the current renewed commitment for its control or elimination. 1 , 2 The malaria vaccine contains the RTS,S antigen formulated with one of two adjuvant systems (AS), AS01 or AS02, and targets the pre-erythrocytic stage of Plasmodium falciparum parasite. This vaccine also has the potential to provide protection against infection with hepatitis B virus, since it contains the hepatitis B surface antigen. Studies conducted thus far show that the vaccine has a promising safety profile, is immunogenic, and confers partial protection against . . .