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BibTeX
Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis
NMR in biomedicine, 2008-07, Vol.21 (6), p.589-597
Budde, Matthew D.
Kim, Joong Hee
Liang, Hsiao-Fang
Russell, John H.
Cross, Anne H.
Song, Sheng-Kwei
2008
Details
Autor(en) / Beteiligte
Budde, Matthew D.
Kim, Joong Hee
Liang, Hsiao-Fang
Russell, John H.
Cross, Anne H.
Song, Sheng-Kwei
Titel
Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis
Ist Teil von
NMR in biomedicine, 2008-07, Vol.21 (6), p.589-597
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2008
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Recent studies have suggested that axonal damage, and not demyelination, is the primary cause of long‐term neurological impairment in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). The axial and radial diffusivities derived from diffusion tensor imaging have shown promise as non‐invasive surrogate markers of axonal damage and demyelination, respectively. In this study, in vivo diffusion tensor imaging of the spinal cords from mice with chronic EAE was performed to determine if axial diffusivity correlated with neurological disability in EAE assessed by the commonly used clinical scoring system. Axial diffusivity in the ventrolateral white matter showed a significant negative correlation with EAE clinical score and was significantly lower in mice with severe EAE than in mice with moderate EAE. Furthermore, the greater decreases in axial diffusivity were associated with greater amounts of axonal damage, as confirmed by quantitative staining for non‐phosphorylated neurofilaments (SMI32). Radial diffusivity and relative anisotropy could not distinguish between the groups of mice with moderate EAE and those with severe EAE. The results further the notion that axial diffusivity is a non‐invasive marker of axonal damage in white matter and could provide the necessary link between pathology and neurological disability. Copyright © 2007 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0952-3480
eISSN: 1099-1492
DOI: 10.1002/nbm.1229
Titel-ID: cdi_proquest_miscellaneous_69248287
Format
–
Schlagworte
Animals
,
axial diffusivity
,
axonal damage
,
Demyelinating Diseases - pathology
,
demyelination
,
Diffuse Axonal Injury - pathology
,
Diffusion Magnetic Resonance Imaging - methods
,
diffusion tensor imaging
,
Disease Models, Animal
,
experimental autoimmune encephalomyelitis
,
Humans
,
Image Interpretation, Computer-Assisted - methods
,
Male
,
Mice
,
Mice, Inbred C57BL
,
Multiple Sclerosis - diagnosis
,
Nervous System Diseases - pathology
,
radial diffusivity
,
Reproducibility of Results
,
Sensitivity and Specificity
,
spinal cord
,
Spinal Cord - pathology
,
Statistics as Topic
,
white matter
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