Details

Autor(en) / Beteiligte

• Wang, Rui
• Lagakos, Stephen W
• Ware, James H
• Hunter, David J
• Drazen, Jeffrey M

Titel

Statistics in Medicine — Reporting of Subgroup Analyses in Clinical Trials

Ist Teil von

• The New England journal of medicine, 2007-11, Vol.357 (21), p.2189-2194

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The analysis of subgroups is often used as a way to glean additional information from data sets. The strengths and weaknesses of this approach and new Journal policies concerning the reporting of subgroup analyses are discussed in this article. The strengths and weaknesses of subgroup analyses and new Journal policies concerning the reporting of this approach are discussed in this article. Medical research relies on clinical trials to assess therapeutic benefits. Because of the effort and cost involved in these studies, investigators frequently use analyses of subgroups of study participants to extract as much information as possible. Such analyses, which assess the heterogeneity of treatment effects in subgroups of patients, may provide useful information for the care of patients and for future research. However, subgroup analyses also introduce analytic challenges and can lead to overstated and misleading results. 1 – 7 This report outlines the challenges associated with conducting and reporting subgroup analyses, and it sets forth guidelines for their use in the . . .