Details

Autor(en) / Beteiligte

• Ang, C.W.
• Krogfelt, K.
• Herbrink, P.
• Keijser, J.
• van Pelt, W.
• Dalby, T.
• Kuijf, M.
• Jacobs, B.C.
• Bergman, M.P.
• Schiellerup, P.
• Visser, C.E.

Titel

Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain–Barré and reactive arthritis patients

Ist Teil von

• Clinical microbiology and infection, 2007-09, Vol.13 (9), p.915-922

Ort / Verlag

Oxford, UK: Elsevier Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Weeks or months following Campylobacter infection, a small proportion of infected individuals develop Guillain–Barré syndrome (GBS) or reactive arthritis (ReA). Stool culture for Campylobacter is often negative in these patients, and serology is therefore the method of choice for diagnosing a recent infection with Campylobacter. This study developed a capture ELISA system to detect anti-Campylobacter IgA and IgM antibodies indicative of a recent infection. The sensitivity of the assay was 82.0% in uncomplicated Campylobacter enteritis patients, 96.2% in GBS patients who were culture-positive for Campylobacter, and 93.1% in culture-positive ReA patients, with a specificity of 93.0%. The assay allows identification of Campylobacter infection in patients with post-infectious neurological and rheumatological complications.